Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular m…
In societies all around the globe, the population is aging. This fact will pose important challenges to healthcare and social systems in industrialized and emerging economies alike. It is therefore critical to devise strategies to extend the healthy years of life and thus limit the exponential increase in healthcare cost associated with growing old and frail. Understanding the aging process …