Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. Various cells, including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others have had protective or regenerative effects in animal models. The proposed book will address recent research on all relevant cell types. In addi…
This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phe…
Much of what is known about the universe came from the study of celestial shadows. This book looks in detail at the way eclipses and other celestial shadows have given us amazing insights into the nature of the objects in our solar system and how they are even helping us discover and analyze planets that orbit stars other than our Sun. A variety of eclipses, transits, and occultations of the mo…
This book explores the double coding property of DNA, which is manifested in the digital and analog information types as two interdependent codes. This double coding principle can be applied to all living systems, from the level of the individual cell to entire social systems, seen as systems of communication. Further topics discussed include the ubiquitous problem of logical typing, which refl…
This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and euka…
This book reconceptualises the role of the general meeting and shareholders in the listed companies in four leading common law jurisdictions in Asia (Singapore, Hong Kong, India and Malaysia) as one that should include fiduciary duties. It demonstrates why, when, by whom and how fiduciary duties should be imposed and how they could be enforced. In so doing, it refutes the long-standing common l…
Born in Ireland, William Marsden (1754–1836) was a pioneer in the study of oriental languages, in particular those of modern-day Malaysia and Indonesia. At the age of seventeen he joined his elder brother to work for the East India Company in Sumatra, and began researching the languages of the East Indies. He moved to London in 1779 and became associated with its scientific and academic circl…
The leading antiquary of his day, Richard Gough (1735–1809) served as director of the Society of Antiquities for over twenty-five years. The only son of a wealthy family, Gough benefited from being free to pursue his interests without hindrance. His independent fortune allowed him both to conduct his own research and to aid others with theirs. While the topography and Roman antiquities of the…
This book focuses on the current clinical practice, outcome and the future development of Total Knee Arthroplasty (TKA) in surgical settings. A major objective of this work is to address “What is the optimal design and fixation of the implants we use for knee arthroplasty reconstruction? What are the gold standards? and, Can we do better?”. In an attempt to throw light on these questions, t…