Brazil is renowned worldwide for its remarkable reforms in pharmaceutical regulation, which have enhanced access to essential medicines while lowering drug costs. This book innovates by analysing the generic drug reform in Brazil, demonstrating that pharmaceutical regulation is only partially influenced by non-state actors. Little is known about the institutional antecedents and policy process…
This book focuses on the modeling and analysis of heat and fluid flow in microchannels and micro-systems, compiling a number of analytical and hybrid numerical-analytical solutions for models that account for the relevant micro-scale effects, with the corresponding experimental analysis validation when applicable. The volume stands as the only available compilation of easy to use analytically-b…
This book draws readers’ attention to the financial aspects of daily life at a corporation by combining a robust mathematical setting and the explanation and derivation of the most popular models of the firm. Intended for third-year undergraduate students of business finance, quantitative finance, and financial mathematics, as well as first-year postgraduate students, it is based on the twin …
In this brief the authors establish a new frequency-sweeping framework to solve the complete stability problem for time-delay systems with commensurate delays. The text describes an analytic curve perspective which allows a deeper understanding of spectral properties focusing on the asymptotic behavior of the characteristic roots located on the imaginary axis as well as on properties invariant …
This book highlights recent compelling research results and trends in various aspects of contemporary mathematics, emphasizing applicabilitions to real-world situations. The chapters present exciting new findings and developments in situations where mathematical rigor is combined with common sense. A multi-disciplinary approach, both within each chapter and in the volume as a whole, leads to pr…
Carolin Loos introduces two novel approaches for the analysis of single-cell data. Both approaches can be used to study cellular heterogeneity and therefore advance a holistic understanding of biological processes. The first method, ODE constrained mixture modeling, enables the identification of subpopulation structures and sources of variability in single-cell snapshot data. The second method …
This book provides readers with the fundamental, analytical, and quantitative knowledge of machining process planning and optimization based on advanced and practical understanding of machinery, mechanics, accuracy, dynamics, monitoring techniques, and control strategies that they need to understanding machining and machine tools. It is written for first-year graduate students in mechanical eng…
This brief examines a deterministic, ODE-based model for gene regulatory networks (GRN) that incorporates nonlinearities and time-delayed feedback. An introductory chapter provides some insights into molecular biology and GRNs. The mathematical tools necessary for studying the GRN model are then reviewed, in particular Hill functions and Schwarzian derivatives. One chapter is devoted to the ana…
This book discusses the economic, political, and environmental issues surrounding the international exploration and exploitation of conventional and unconventional natural gas. Shale gas development in recent years has changed the energy discussion in the US as existing reserves of natural gas coupled with horizontal drilling and hydraulic fracturing make exploitation of these reserves economic…
This textbook presents the mathematical theory and techniques necessary for analyzing and modeling high-performance global networks, such as the Internet. The three main building blocks of high-performance networks are links, switching equipment connecting the links together and software employed at the end nodes and intermediate switches. This book provides the basic techniques for modeling an…