About this book This thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo. T…
This book provides readers with a variety of tools to address the challenges posed by hot carrier degradation, one of today’s most complicated reliability issues in semiconductor devices. Coverage includes an explanation of carrier transport within devices and book-keeping of how they acquire energy (“become hot”), interaction of an ensemble of colder and hotter carriers with defect prec…
This edited volume focuses on parasite-host relationships and the behavioral changes parasites may trigger in their hosts. Parasites have developed strategies which enhance their chances to find a host to survive inside its body and to become most easily transmitted to one another. Many of these parasites influence the host’s behavior by various mechanisms, so that the rate of their transmiss…
This edited volume focuses on parasite-host relationships and the behavioral changes parasites may trigger in their hosts. Parasites have developed strategies which enhance their chances to find a host to survive inside its body and to become most easily transmitted to one another. Many of these parasites influence the host’s behavior by various mechanisms, so that the rate of their transmiss…
This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic potential not only of antibacterial, but also of antifungal, antiviral, plant antimic…
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehen…
This textbook on algebraic topology updates a popular textbook from the golden era of the Moscow school of I. M. Gelfand. The first English translation, done many decades ago, remains very much in demand, although it has been long out-of-print and is difficult to obtain. Therefore, this updated English edition will be much welcomed by the mathematical community. Distinctive features of this boo…
During the nineteenth century, social reformers took hold of an already existing institution—the school—and sought to make it compulsory. In the process, they supplanted parents and domestic life—the home—as the primary educational force for children As education was taken out of the home, American classrooms were at the same time remade into a particular kind of home life—one based …
This thesis presents a theoretical and experimental approach for the rapid fabrication, optimization and testing of holographic sensors for the quantification of pH, organic solvents, metal cations, and glucose in solutions. Developing non-invasive and reusable diagnostics sensors that can be easily manufactured will support the monitoring of high-risk individuals in any clinical or point-of…
Lighthearted, quirky, and upbeat, this book explores the portrayal of science and technology on both the big and little screen -- and how Hollywood is actually doing a better job of getting it right than ever before. Grounded in the real-word, and often cutting-edge, science and technology that inspires fictional science, the authors survey Hollywood depictions of topics such as quantum mechani…