Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular m…
Buku ini mengkaji hukum yang berkaitan dengan kepemilikan, ancaman, atau penggunaan senjata nuklir. Dengan membahas secara berurutan hukum tentang kedaulatan, hukum ancaman atau penggunaan kekuatan, pelaksanaan permusuhan nuklir, netralitas, undang-undang senjata dan kejahatan perang.
This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions …
This successful book gives an introduction to the basics of aerothermodynamics, as applied in particular to winged re-entry vehicles and airbreathing hypersonic cruise and acceleration vehicles. The book gives a review of the issues of transport of momentum, energy and mass, real-gas effects as well as inviscid and viscous flow phenomena. In this second, revised edition the chapters with the cl…
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin …
This biography sheds light on all facets of the life and the achievements of Ernst Zermelo (1871-1953). Zermelo is best-known for the statement of the axiom of choice and his axiomatization of set theory. However, he also worked in applied mathematics and mathematical physics. His dissertation, for example, promoted the calculus of variations, and he created the pivotal method in the theory of …
The book covers the most crucial parts of real-time hyperspectral image processing: causality and real-time capability. Recently, two new concepts of real time hyperspectral image processing, Progressive HyperSpectral Imaging (PHSI) and Recursive HyperSpectral Imaging (RHSI). Both of these can be used to design algorithms and also form an integral part of real time hyperpsectral image processin…
This work presents modern implementations of relevant molecular dynamics algorithms using ls1 mardyn, a simulation program for engineering applications. The text focuses strictly on HPC-related aspects, covering implementation on HPC architectures, taking Intel Xeon and Intel Xeon Phi clusters as representatives of current platforms. The work describes distributed and shared-memory parallelizat…
This monograph provides a field-proven approach to analyze industrial production with a cross-company scope as well as regarding all hierarchical system levels of manufacturing enterprises. The book exemplifies this approach in the context of aluminum die casting, and presents a set of measures which allow a 30 percent energy reduction along the value chain. The target audience primarily compri…
The purpose of these notes is to provide an introduction to the Malliavin calculus and its recent application to quantitative results in normal approximations, in combination with Stein’s method. The basic differential operators of the Malliavin calculus and their main properties are presented. We explain the connection of these operators with the Wiener chaos expansion and the Ornstein-Uh…