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Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of…
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock an…
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- 978-4-431-55447-9
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Total Knee Arthroplasty A Comprehensive Guide
This book offers a comprehensive guide to total knee arthroplasty (TKA) that will assist in achieving excellent outcomes based on a sound understanding and technique. After an introductory section on the native knee that covers the anatomy, physiology, biomechanics, and patterns of disease, all aspects of primary knee arthroplasty are discussed in detail. Individual chapters are devoted to topi…
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- 978-3-319-17554-6
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A Catalogue of the Bradshaw Collection of Irish Books in the University Libra…
University Librarian at Cambridge from 1867 until his death, Henry Bradshaw (1831–86) had inherited from his banker father an important library of Irish printed books and pamphlets assembled in the early nineteenth century. Having added to it, Bradshaw generously presented the collection to the University Library in 1870, and it has been expanding ever since. Published in 1916, this three-vol…
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- 9781107446304
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A Brief Narrative of an Unsuccessful Attempt to Reach Repulse Bay: Through Si…
This short work, featuring a number of attractive engravings, traces an abortive expedition to the Canadian Arctic. George Francis Lyon (1795–1832), naval officer and explorer, had accompanied William Parry on a previous expedition in search of the North-West Passage. In 1824 Lyon was instructed to return to Repulse Bay and to explore the mainland. Unfavourable weather conditions forced Lyon …
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- 9781107281202
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A Brief History of Geology
Geology as a science has a fascinating and controversial history. Kieran D. O'Hara's book provides a brief and accessible account of the major events in the history of geology over the last two hundred years, from early theories of Earth structure during the Reformation, through major controversies over the age of the Earth during the Industrial Revolution, to the more recent twentieth-century …
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- 9781316809990
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Total Knee Arthroplasty Long Term Outcomes
This book focuses on the current clinical practice, outcome and the future development of Total Knee Arthroplasty (TKA) in surgical settings. A major objective of this work is to address “What is the optimal design and fixation of the implants we use for knee arthroplasty reconstruction? What are the gold standards? and, Can we do better?”. In an attempt to throw light on these questions, t…
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- 978-1-4471-6660-3
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A Brief History of English Syntax
In its 1500-year history, the English language has seen dramatic grammatical changes. This book offers a comprehensive and reader-friendly account of the major developments, including changes in word order, the noun phrase and verb phrase, changing relations between clausal constituents and the development of new subordinate constructions. The book puts forward possible explanations for change,…
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- 9781139049559
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Topology and Geometric Group Theory Ohio State University, Columbus, USA, 20…
This book presents articles at the interface of two active areas of research: classical topology and the relatively new field of geometric group theory. It includes two long survey articles, one on proofs of the Farrell–Jones conjectures, and the other on ends of spaces and groups. In 2010–2011, Ohio State University (OSU) hosted a special year in topology and geometric group theory. Over t…
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- 978-3-319-43674-6
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Topology
This is an introductory textbook on general and algebraic topology, aimed at anyone with a basic knowledge of calculus and linear algebra. It provides full proofs and includes many examples and exercises. The covered topics include: set theory and cardinal arithmetic; axiom of choice and Zorn's lemma; topological spaces and continuous functions; connectedness and compactness; Alexandrov comp…
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- 978-3-319-16958-3
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A Brief History of Economic Thought
The evolution of economic thought can be traced back from its beginnings in classical antiquity up to the present day. In this book, Professor Alessandro Roncaglia offers a clear, concise and updated version of his award-winning The Wealth of Ideas, studying the development of economic thought through perspectives and debates on the economy and society over time. With chapters on prominent econ…
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- 9781316798416
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