Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assem…
This book summarizes recent advances in understanding the functions of plant and algal lipids in photosynthesis, in development and signaling, and in industrial applications. As readers will discover, biochemistry, enzymology and analytical chemistry, as well as gene knock-out studies have all contributed to our rapidly increasing understanding of the functions of lipids. In the past few decade…
Lipids and Skin Health is the first effort to summarize and review the studies, ideas, and research that link lipid metabolism to the largest organ of our body, the skin. The book covers the fundamental biology of the skin, and the major involvement of the transcriptional factors that govern lipid synthesis and the bioactive lipids in this intriguing organ. All layers of skin are presented, as…
What are lipid nanoparticles? How are they structured? How are they formed? What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current prac…
This timely, concise title provides an important update on clinical lipid management. Using information from recent clinical trials and in special populations, the book begins by offering an easy-to-read overview of LDL, HDL, and triglyceride metabolism and the genetics of lipid disorders. The link between inflammation and lipids, and how this relates to atherosclerosis development, is also add…
Linux and Solaris Recipes for Oracle DBAs, 2nd Edition is an example–based book on managing Oracle Database under Linux and Solaris. The book is written for database administrators who need to get work done and lack the luxury of curling up fireside with a stack of operating-system documentation. What this book provides instead is task-oriented coverage designed around the needs of the Oracle…
This book provides a wide variety of algorithms and models to integrate linguistic knowledge into Statistical Machine Translation (SMT). It helps advance conventional SMT to linguistically motivated SMT by enhancing the following three essential components: translation, reordering and bracketing models. It also serves the purpose of promoting the in-depth study of the impacts of linguistic know…
"Robert Pearl, a well-known DBA in the SQL community, explains his holistic vision of a database instance that needs regular check-ups and gives the tools, scripts, and best practices he has collected over the years." Alberto Bolchini, Computing Reviews, May 9, 2016 Healthy SQL is about ensuring the ongoing performance health of a SQL Server database. An unhealthy database is not just an inc…
Hair health is a core benefit of products produced for consumers by the cosmetic industry, and more than 70% of women claim to want healthy hair. However, there is very little clarity in the industry as to the meaning of healthy hair in a consumer context and the technical factors that control what the consumer perceives as hair health. Providing updated information on how to prevent and res…
This timely professional reference and educational resource applies current concepts of pediatric adherence to medical treatment to create a model for a family-centered, collaborative approach to managing chronic illness. At its core are the latest findings on adherence: the factors that encourage it, the barriers that derail it, and the most effective interventions for its improvement. The boo…