Cellular plasticity is modulated by protein posttranslational modifications, which act on most intracellular pathways. Ubiquitination is a versatile posttranslational modification (PTM) that influences protein fate, controlling their degradation or modulating their activity and subcellular localization. The ubiquitin proteasome system, UPS, and the autophagic pathway are the main degradative in…
The aim of this paper is to analyse two ethnographic identities constructed for two barbarian peoples – the Ostrogoths and the Langobards. As I try to argue, the first identity was constructed to show that the Ostrogoths were a civilized people and a better version of the Romans, and moreover, this identity communicated that the Ostrogoths could not be called a barbaric and savage people. The…
The purpose of this paper is to update the study and analysis of the administration of Karkemish during the final phase of the Hittite kingdom. The first introductory part outlines previous contributions and results. The second part presents the updated lists of princes and officials belonging to the court of Karkemish. The third part attempts to place princes and officials in chronological ord…
Assessing the value for money offered by new health technologies is playing an increasingly important role in aiding decision-making in health and care. Even in a pre-COVID-19 world, international healthcare systems were struggling to meet the demands of their patient populations and the rising cost of new health technologies, such as pharmaceuticals. With the impact of the corona virus pandemi…
Earth sciences
This good practice essay puts the Community Education Program (CEP) as a focus for comparison between West Virginia (USA) and Germany/European Union (EU). The essay is a combination of reflections on qualification frameworks, learning outcomes, lifelong learners/learning, transnational organisations, the Scottish Framework, a number of good practices, and accreditation from a research and pract…
The sequencing of the entire human genome has opened up unprecedented possibilities for healthcare, but also ethical and social dilemmas about how these can be achieved, particularly in developing countries. UNESCO's Bioethics Programme was established to address such issues in 1993. Since then, it has adopted three declarations on human genetics and bioethics (1997, 2003 and 2005), set up nume…
Background: A growing body of scientific literature points to the consequences of various factors related to housing status on the well-being of individuals, particularly the elderly. This project aims to develop models that guarantee high-quality care for older people living in the province of Bolzano based on quantitative data analysis. Current changes within the family structure make it incr…
What of the job market in the era of Brexit and in the international arena of the Trump presidency? Naturally, there are various perspectives, but forms of emotive or propagandist rhetoric threaten to hold sway here. Above all, Guidance Towards the Job market means recognizing the complexities of geopolitical change within our information-sharing and collaborative networks, as well as the vario…
Our research compares guild ordinances, judicial proceedings, technical manuals of dyeing and especially fiscal sources in the Valencian archives to check the fashion trends on the colour of silks fabrics during the 15th-16th centuries in relation to what was happening in the European market at that time. The silk declarations in Valencia city from 1475 to 1513 makes it possible to establish a …