This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text context…
This books discusses the design, electrical simulation and layout of a 2nd-order ∑∆ analog-to-digital converter (ADC), using oxide thin-film transistors (TFTs) technology. The authors provide a unified view of materials science and electronics engineering, in order to guide readers from both fields through key topics. To accomplish this goal, background regarding materials, device physics, …
This book reviews the current state of information on reactive oxygen and nitrogen species and their role in cell communication during plant growth, development and adaptation to stress conditions. It addresses current research advances made in the area of reactive oxygen and nitrogen species (ROS and RNS) signaling. These free radical molecules are important in plant-microbe interactions, r…
This well-known introductory textbook gives a uniform presentation of nuclear and particle physics from an experimental point of view. The first part, Analysis, is devoted to disentangling the substructure of matter. This part shows that experiments designed to uncover the substructures of nuclei and nucleons have a similar conceptual basis, and lead to the present picture of all matter bein…
This book is an introduction to “multi-messenger” astrophysics. It covers the many different aspects connecting particle physics with astrophysics and cosmology and introduces astrophysics using numerous experimental findings recently obtained through the study of high-energy particles. Taking a systematic approach, it comprehensively presents experimental aspects from the most advan…
Rather than focusing on the contributions of theoretical physicists to the understanding of the subatomic world and of the beginning of the universe - as most popular science books on particle physics do - this book is different in that, firstly, the main focus is on machine inventors and builders and, secondly, particle accelerators are not only described as discovery tools but also for their …
This book provides detailed and comprehensive information on oxidative damage caused by stresses in plants with especial reference to the metabolism of reactive oxygen species (ROS). In plants, as in all aerobic organisms, ROS are common by-products formed by the inevitable leakage of electrons onto O2 from the electron transport activities located in chloroplasts, mitochondria, peroxisomes …
This brief goes back to basics and describes the Quantitative structure-activity/property relationships (QSARs/QSPRs) that represent predictive models derived from the application of statistical tools correlating biological activity (including therapeutic and toxic) and properties of chemicals (drugs/toxicants/environmental pollutants) with descriptors representative of molecular structure and/…
This book is an introduction to the theory of Hilbert space, a fundamental tool for non-relativistic quantum mechanics. Linear, topological, metric, and normed spaces are all addressed in detail, in a rigorous but reader-friendly fashion. The rationale for an introduction to the theory of Hilbert space, rather than a detailed study of Hilbert space theory itself, resides in the very high mathem…
This book is a concise introduction to electromagnetics and electromagnetic fields that covers the aspects of most significance for engineering applications by means of a rigorous, analytical treatment. After an introduction to equations and basic theorems, topics of fundamental theoretical and applicative importance, including plane waves, transmission lines, waveguides and Green's functions, …