This collective monograph aims at contributing to an improved understanding of the epistemic presumptions, sociocultural implications and historically backgrounds of the newly emerging and currently expanding approach of systems biology. In doing so, it offers empirically grounded, valuable and reflexive information about a paradigmatic shift in the biosciences for a wide range of scientists wo…
This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making frameworks for: (1) rejecting the null hypothesis (stopping for efficacy), (2) rejecting the alternative hypothesis (stopping for futility), and (3) rejecting the null or alternative hypothesis (stopping for either futility or efficacy), where the trial is designed to evaluat…
This book constitutes the refereed proceedings of the 5th International Workshop on the Arithmetic of Finite Field, WAIFI 2014, held in Gebze, Turkey, in September 2014. The 9 revised full papers and 43 invited talks presented were carefully reviewed and selected from 27 submissions. This workshop is a forum of mathematicians, computer scientists, engineers and physicists performing research on…
This book presents a comprehensive and unifying approach to articular contact mechanics with an emphasis on frictionless contact interaction of thin cartilage layers. The first part of the book (Chapters 1-4) reviews the results of asymptotic analysis of the deformational behavior of thin elastic and viscoelastic layers. A comprehensive review of the literature is combined with the authors' ori…
This book constitutes the thoroughly refereed post-workshop proceedings of the 12th International Workshop on Approximation and Online Algorithms, WAOA 2014, held in Wrocław, Poland, in September 2014 as part of ALGO 2014. The 22 revised full papers presented were carefully reviewed and selected from 49 submissions. They cover a wide range of topics such as coloring and partitioning, compet…
This book constitutes the thoroughly refereed post-workshop proceedings of the 13th International Workshop on Approximation and Online Algorithms, WAOA 2015, held in Patras, Greece, in September 2015 as part of ALGO 2015. The 17 revised full papers presented were carefully reviewed and selected from 40 submissions. Topics of interest for WAOA 2015 were: algorithmic game theory, algorithmic t…
The main goal of this book is to find the constructive content hidden in abstract proofs of concrete theorems in Commutative Algebra, especially in well-known theorems concerning projective modules over polynomial rings (mainly the Quillen-Suslin theorem) and syzygies of multivariate polynomials with coefficients in a valuation ring. Simple and constructive proofs of some results in the theory …
This contribution to SpringerBriefs in Green Chemistry outlines and discusses the four major green chemistry metrics (atom economy, reaction mass efficiency, E factor and process mass intensity), at a level that is comprehensible by upper-level undergraduates. Such students have previously received fundamental training in organic chemistry basics, and are ideally positioned to learn about green…
This book presents a wide range of well-known and less common methods used for estimating the accuracy of probabilistic approximations, including the Esseen type inversion formulas, the Stein method as well as the methods of convolutions and triangle function. Emphasising the correct usage of the methods presented, each step required for the proofs is examined in detail. As a result, this textb…
Focusing on two central conjectures of Asymptotic Geometric Analysis, the Kannan-Lovász-Simonovits spectral gap conjecture and the variance conjecture, these Lecture Notes present the theory in an accessible way, so that interested readers, even those who are not experts in the field, will be able to appreciate the treated topics. Offering a presentation suitable for professionals with little …