Designed as an introduction for both advanced students in aerospace engineering and existing aerospace engineers, this book covers both engineering theory and professional practice in establishing the airworthiness of new and modified aircraft. Initial Airworthiness includes: · how structural, handling, and systems evaluations are carried out; · the processes by which safety and fit…
This book provides an overview of circadian rhythms and cellular networks in their relation to biological systems and dynamical medicine. Six concise chapters explore circadian cell rhythms and biomarkers in inflammation, cardiovascular disease, cancer, depression, and more in causing and treating these ailments. The final chapter discusses optimization of drug delivery and individualized treat…
This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phe…
The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the foc…
Much of what is known about the universe came from the study of celestial shadows. This book looks in detail at the way eclipses and other celestial shadows have given us amazing insights into the nature of the objects in our solar system and how they are even helping us discover and analyze planets that orbit stars other than our Sun. A variety of eclipses, transits, and occultations of the mo…
This book constitutes the refereed proceedings of the 21st International Conference on DNA Computing and Molecular Programming, DNA 21, held in Boston and Cambridge, MA, USA, in August 2015. The 13 full papers presented were carefully selected from 63 submissions. The papers address all current issues related to biomolecular computing, such as: algorithms and models for computation on biomolecu…
This book explores the double coding property of DNA, which is manifested in the digital and analog information types as two interdependent codes. This double coding principle can be applied to all living systems, from the level of the individual cell to entire social systems, seen as systems of communication. Further topics discussed include the ubiquitous problem of logical typing, which refl…
This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. As the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological r…
This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, a…