This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, a…
This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and euka…
This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter ge…
This book shows how video technology can be used to inform teachers’ personal practice, and provides new data and real-world case studies not covered by any previous book on the subject. Initial chapters explore how practicing teachers can view their own recorded lessons and take steps to improve their methods, while subsequent chapters examine how pre-service and in-service teachers can use…
This book is an important volume in the series on the state-of-art research in Cartography and GI Science. It is a collection of selected peer-reviewed papers organized into contemporary topics of research, presented at the 27th International Cartographic Conference (ICC) in Rio de Janeiro. This is the 3rd edition of selected ICA conference papers published by Springer Lectures in Geoinformatio…
In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This first volume provides a comprehensive overview on the basic composition and development of cartilaginous tissues followed by the description of the major signaling pathways which regulate cartilage morphogenesis and function. This book addresses Profe…
In this book we first review the ideas of Lie groupoid and Lie algebroid, and the associated concepts of connection. We next consider Lie groupoids of fibre morphisms of a fibre bundle, and the connections on such groupoids together with their symmetries. We also see how the infinitesimal approach, using Lie algebroids rather than Lie groupoids, and in particular using Lie algebroids of vector…
The standard substrate complexation mechanism engages natural binding sites. In contrast, supramolecular structures may form complexes with proteins by penetrating in regions which are either naturally unstable or become temporarily accessible due to structural rearrangements related to the protein’s function. This may result in enhancement of irreversible processes (e.g. immune complexat…
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This Special Issue aims to be a compilation of new results in the areas of differential and difference Equations, covering boundary value problems, systems of differential and difference equations, as well as analytical and numerical methods. The objective is to provide an overview of techniques used in these different areas and to emphasize their applicability to real-life phenomena, by the in…