The book reports on a novel approach for holistically identifying the relevant state drivers of complex, multi-stage manufacturing systems. This approach is able to utilize complex, diverse and high-dimensional data sets, which often occur in manufacturing applications, and to integrate the important process intra- and interrelations. The approach has been evaluated using three scenarios from d…
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic …
This comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction…
Now, based on the apoB algorithm, that is outlined and illustrated in this book, family physicians as well as cardiologists, endocrinologists and internists will be able to easily and accurately identify and treat these disorders. The apoB dyslipoproteinemias are major common causes of vascular disease. But until now, accurate diagnosis has not been possible. With just total cholesterol, …
With the advent of less invasive treatments for aortic stenosis including percutaneous and apical replacement, more patients are being offered this technology. As such, determining the true severity of aortic stenosis is becoming paramount. Many clinical scenarios occur where the area and gradient estimates of severity do not match. This book will present case by case examples of different pa…
This volume provides a comprehensive, state-of-the-art overview of the major issues specific to the field of antireflux surgery. It provides exceptional instructional detail regarding performance of antireflux surgery from leading esophageal surgeons around the world. This volume represents the only resource of its kind dedicated specifically to the issues unique to antireflux surgery. It is ri…
This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained. The main clinical manifestati…
Dental erosion adversely affects the aesthetics, function, and longevity of the dentition of adults and children alike, and its increasing incidence and prevalence are the source of growing concern. In response, many studies have been conducted on the condition during the past two decades, giving rise to diverse evidence-based management and prevention strategies. Familiarity with these strateg…
For design purposes one needs to relate the structure of proposed materials to their NLO (nonlinear optical) and other properties, which is a situation where theoretical approaches can be very helpful in providing suggestions for candidate systems that subsequently can be synthesized and studied experimentally. This brief describes the quantum-mechanical treatment of the response to one or more…
This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal prope…