This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other t…
Featuring research from Aotearoa (New Zealand), Bangladesh, Canada, Poland, South Africa, and the United States on matters as diverse as anti-poverty organizing, prisoners’ re-entry, anti-fracking campaigns, left-inspired think-tank development, non-governmental partnerships, involuntary psychiatric admission, and perils of immigration medical examination, contributors to this volume adopt a …
This book provides a practical hands-on approach to the management of patients with diabetes and cardiovascular disease, with original and up-to-date coverage of a variety of aspects of emerging clinical importance. Practical advice is offered on diagnosis, risk stratification, management of cardiovascular risk factors, and available drug therapies. Appropriate myocardial revascularization stra…
At the place known as Head-Smashed-In in southwestern Alberta, Aboriginal people practiced a form of group hunting for nearly 6,000 years before European contact. The large communal bison traps of the Plains were the single greatest food-getting method ever developed in human history. Hunters, working with their knowledge of the land and of buffalo behaviour, drove their quarry over a cliff and…
Presenting recent advances in clinical diagnosis and treatment derived from an increased understanding of the biology of the hip, this unique text examines hip disease and pathophysiology through the lenses of kinematics, biomechanics, anatomy and metabolism. Opening chapters examine the impact of health care organization on hip care and prevalence and burden of osteoarthritis. Biomechanical co…
This book provides an overview of pulmonary hypertensive diseases, the current understanding of their pathobiology, and a contemporary approach to diagnosis and treatment. It discusses the definition and classification of these disorders and the epidemiology of pulmonary arterial hypertension (PAH); explores the approach to diagnosis and evaluation via methods such as echocardiography, right he…
This book presents the views of leading European experts on the diagnosis and management of testicular cancer, with coverage of current hot topics in the field. It opens by providing an overview of the recommendations in the most recent consensus paper from the European Germ Cell Cancer Consensus Group, which is based on interdisciplinary cooperation among urologists, medical oncologists, radio…
This volume develops results on continuous time branching processes and applies them to study rate of tumor growth, extending classic work on the Luria-Delbruck distribution. As a consequence, the author calculate the probability that mutations that confer resistance to treatment are present at detection and quantify the extent of tumor heterogeneity. As applications, the author evaluate ovaria…
This volume provides a comprehensive review of the clinical, radiological and clinical aspects in the disease process. The text provides the general pathologist, clinician and pulmonary pathologist with a framework on how to work up a case of either non-neoplastic or neoplastic lung disease and provide clinically relevant information to all involved in patient care. The basic understanding of r…
Diagnostic Cytopathology Board Review and Self-Assessment provides a comprehensive systems-based review of non-gynecological cytology including cytomorphology, pitfalls and ancillary studies, presented in a high-yield format with board-type multiple choice questions and detailed answers. It provides an excellent review, resource and self-assessment for pathologists, cytopathologists and cytotec…