The immune system detects "danger", through a series of what we now call damage associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. DAMPS also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory…
Recent advances in computer technologies and research now enable to simulate realistic social interaction thanks to the use of increasingly complex computer models. Virtual agents reproducing both human appearance and expressive behaviors are now available for supporting affective interactions with users. Two deeply intertwined fields of knowledge already benefit from such innovations concernin…
Family involvement characterizes a large number of firms around the world and is thought to significantly impact their strategies, behavior, and performance. Family involvement occurs when a family exerts control over the firm through ownership and management. When family involvement leads to intentions to pursue particularistic goals and strategies, controlling families are more likely to exer…
Supercomputing facilities are becoming increasingly available in neuroscience, predominantly for simulating the dynamics of electrical activity propagating through neuronal circuits. On today's most advanced supercomputers, large-scale models can be simulated with up to a billion of neurons. However, merely further increasing the number of neurons and synapses will not be sufficient to create b…
Designed as an easy-to-use, practical guide to tumors of the eye, lids, and orbit, this open access book comprehensively addresses surgical treatment and management of diseases related to ophthalmic oncology. Surgical Ophthalmic Oncology: A Collaborative Open Access Reference is an ideal reference for general ophthalmologists, surgeons, fellows and trainees around the world who encounter these …
This book focuses on modern methods of oscillation analysis in machines, including cyclic action mechanisms (linkages, cams, steppers, etc.). It presents schematization techniques and mathematical descriptions of oscillating systems, taking into account the variability of the parameters and nonlinearities, engineering evaluations of dynamic errors, and oscillation suppression methods. The major…
This open access book is an overview on CT/X-ray contrast media designed for radiologists and other medical specialists who use contrast media in imaging and interventional procedures as well as related scientists on the use and pharmaceutical aspects of X-ray contrast media. The overall goal of this book is to provide a comprehensive overview relevant for the optimal use of x-ray contrast medi…
This White Paper details the status of hip and knee arthroplasty care in Germany. Hip and knee replacements are amongst the most frequently performed procedures and usually become necessarily due to age-related wear of the joint, osteoarthritis and fractures of the femoral neck. In light of demographic change, demands with regard to standards of care and the procedures are likely to rise.This b…
In this book, the author provides a complete process for electronic markets design together with the required en-gineering methods. As such the book is unique applying tech-niques from engineering design to modern Information Systems and Economics. Mr. Neumann succeeds in presenting a generic but coherent approach that is an indispensable aid in designing markets.
This book has been created for students and all individuals who work with children and families (e.g., educators, parents, caregivers, direct support workers, etc.) in diverse contexts. It is imperative to understand how and what factors may influence child outcomes across the lifespan. Therefore, key concepts related to parenting, child-rearing, care-giving, and parenting education are outline…