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Danger Signals Triggering Immune Response and Inflammation

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The immune system detects "danger", through a series of what we now call damage associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. DAMPS also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial or mesenchymal) and injured tissue. Some endogenous danger signals are heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular-matrix breakdown products such as hyaluronan fragments, neuromediators and cytokines like the interferons (IFNs).

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Detail Information

Series Title

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Call Number

617 RAM d

Publisher

: Frontiers Media SA., 2017

Collation

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Language

English

ISBN/ISSN

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Classification

617

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Inflammation

Specific Detail Info

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Statement of Responsibility

Abdulraouf Ramadan, Walter G. Land, Sophie Paczesny

Other Information

Cataloger

rat

Source

-

Validator

maya

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