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Sensory Hair Cell Death and Regeneration
Sensory hair cells are the specialized mechanosensory
receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and
balance. Hair cells can be damaged due to such
factors as agin g, ototoxic chemicals, acoustic trauma,
infection, or genetic factors. Loss of hese hair cells
lead to deficits in hearing and balance, and in ammals, such deficits are permanent. In contrast,
non-mammalian vertebrates exhibit the capability
to regenerate missing hair cells.
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