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Ontogeny and Phylogeny of Brain Barrier Mechanisms

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The brain functions within an internal environment that is determined and controlled by morphological structures and cellular mechanisms present at interfaces between the brain and the rest of the body. In vertebrates these interfaces are across cerebral blood vessels (blood-brain barrier) choroid plexuses (blood-cerebrospinal fluid barrier) and pia-arachnoid. There is a CSF-brain barrier in the neuroepithelium lining the ventricular system that is only present in embryos. There is now substantial evidence that many of the brain barrier mechanisms develop early and that in some cases they are functionally more active and even specialized compared to adult barriers. Therefore barriers in developing brain should be viewed as adapted appropriately for the growing brain and not, as is still widely believed, immature.

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Series Title

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Call Number

617 SAU o

Publisher

: Frontiers Media SA., 2016

Collation

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Language

English

ISBN/ISSN

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Classification

617

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Ontogeny

Specific Detail Info

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Statement of Responsibility

Norman R. Saunders, Helen B. Stolp, Shane A. Liddelow

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Cataloger

rat

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Validator

maya

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