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Stem Cell Processing

The term “stem cell” appeared in the scientifi c literature as early as 1868 in the work
of the eminent German biologist Ernst Haeckel. In this work, Haeckel used the term
Stammzelle (“stem cell”) to describe the ancestor unicellular organism from which
he presumed all multicellular organisms evolved. Particularly, he also suggested
fertilized oocytes as the source giving rise to all cells of the whole body. In 1892,
Valentin Hacker described stem cells as the cells that later produce oocytes in the
gonads. Then, this term becomes more popular with some experimental results in
developmental biology. Some studies about nuclear programming in the 1900s
showed that adult cells can become pluripotent stem cells, and pluripotent stem
cells can differentiate into all specialized cells from three germ layers. The fi rst successful study about epigenetic reprogramming was performed by John Gurdon in
1962 in the African clawed toad, Xenopus laevis . He could produce healthy and
sexually mature fertile frogs by nuclei transplantation from differentiated cells.
Therefore, he and Shinya Yamanaka shared a Nobel Prize in Medicine or Physiology
in 2012. Besides pluripotent stem cells, the multipotent stem cells also were detected
and isolated in the adult, so-called adult stem cells. Adult stem cells such as hematopoietic stem cells and mesenchymal stem cells are the essential source of stem
cells in an adult that play the important roles in tissue homeostasis, wound healing,
and tissue regeneration after injuries. These discoveries suggested that stem cell
transplantation can help to regenerate the injured tissues. And stem cell therapy, as
well as regenerative medicine, was formed from these observations

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Series Title
-
Call Number
-
Publisher
London : Springer.,
Collation
-
Language
English
ISBN/ISSN
978-3-319-40073-0
Classification
NONE
Content Type
text
Media Type
computer
Carrier Type
online resource
Edition
-
Subject(s)
Clinical Applications
Specific Detail Info
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Statement of Responsibility
Other Information
Cataloger
Jemadi
Source
https://link.springer.com/content/pdf/10.1007/978-3-319-40073-0.pdf?pdf=button
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