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Myeloid-Derived Suppressor Cells and Cancer

The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

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Detail Information
Series Title
SpringerBriefs in Immunology
Call Number
-
Publisher
: .,
Collation
IX, 102
Language
English
ISBN/ISSN
978-3-319-26819-4
Classification
NONE
Content Type
-
Media Type
-
Carrier Type
-
Edition
1
Subject(s)
Oncology
Cell Biology
Cancer Biology
Immunology
Specific Detail Info
-
Statement of Responsibility
Other Information
Cataloger
Fandi
Source
-
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No other version available

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