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Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

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Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.

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Availability

No copy data

Detail Information

Series Title

Subcellular Biochemistry

Call Number

-

Publisher

: ., 2015

Collation

XXII, 395

Language

English

ISBN/ISSN

XXII, 395

Classification

NONE

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

1

Subject(s)

Neuroscience
Human Physiology
Developmental Biology and Stem Cells
Animal Physiology

Specific Detail Info

-

Statement of Responsibility

Caroline Fonta

Other Information

Cataloger

Lika

Source

-

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