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Stem Cells and Cardiac Regeneration

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Ischemic heart disease (IHD) and heart failure (HF) are the major causes of
morbidity and mortality in Europe and worldwide. IHD and HF patients could benefi t from therapies that would accelerate natural processes of postnatal collateral
vessel formation and/or muscle regeneration. Although treatment for acute myocardial infarction has improved over the past decades, there are currently no effective
therapies for the associated problem of IHD and HF. Therefore, novel therapeutic
strategies are required in order to reduce the extent of myocardial infarction, preserve cardiac function, and improve clinical outcomes in patients with IHD. The
purpose of this book is to provide an update of recent advances in the basic and
clinical applications of cell-based therapies for myocardial repair and regeneration
in IHD and HF. In this book, cardiologist clinicians and scientists will have an
opportunity to learn about the potential of multipotent and pluripotent stem cells
and all stem cell-based regenerative therapies, aimed at treating these diseases. The
fi rst and second parts of the book cover the basic aspects of stem cells, while subsequent sections will be more dedicated to the clinical application of stem cells for the
treatment of IHD and HF. In particular, Chaps. 1–4 provide defi nitions, isolation
criteria, and characterization of embryonic and adult stem cells, as well as pluripotent stem cells and tissue- specifi c progenitor and stem cells (including adipose,
bone, lung, brain, blood, heart tissues). Chapters 5–9 examine the role of critical
regulators of stem cell differentiation in myocardial regeneration that include circadian rhythms, microRNAs, epigenetics, microvesicles, and exosomes. Chapter 10
assesses the infl uence of cell delivery routes and injectable biomaterials on the
engraftment and effi cacy of transplanted stem cells. Finally, Chap. 11 critically
reviews the use of stem/progenitor cells in cardiac regeneration and discusses current controversies, unresolved issues, challenges, and future directions.

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Detail Information

Series Title

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Call Number

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Publisher

London : Springer., 2016

Collation

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Language

English

ISBN/ISSN

978-3-319-25427-2

Classification

NONE

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Cell Biology

Specific Detail Info

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Statement of Responsibility

Editors: Rosalinda Madonna

Other Information

Cataloger

Jemadi

Source

https://link.springer.com/content/pdf/10.1007/978-3-319-25427-2.pdf?pdf=button

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