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Stem Cells in the Lung

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The last decade has witnessed significant progress in understanding the organization and regulation of regenerative cells in the adult lung. The development and
refinement of multiparameter flow cytometric cell sorting protocols and in vitro
clonogenic assays has enabled the identification, prospective isolation, and characterization of candidate adult lung stem and progenitor cells. Powerful gene labelling
technologies, cell lineage tracing and cell fate mapping protocols, and genetically
engineered mouse models have revealed critical regulatory molecules, mechanisms, pathways, and cellular interactions important in building the lung during
fetal development; and in maintaining lung function and rebuilding the lung in
adulthood. This in turn has advanced the understanding of the pathophysiology of
lung diseases; and how endogenous lung stem and progenitor cells, exogenous stem
cells, and bioengineering technologies might be harnessed to attenuate or reverse
intractable, life-threatening respiratory diseases.

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Detail Information

Series Title

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Call Number

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Publisher

London : Springer., 2015

Collation

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Language

English

ISBN/ISSN

978-3-319-21082-7

Classification

NONE

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

stem cells

Specific Detail Info

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Statement of Responsibility

Editors: Ivan Bertoncello

Other Information

Cataloger

Jemadi

Source

https://link.springer.com/content/pdf/10.1007/978-3-319-21082-7.pdf?pdf=button

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