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Genetics of the Mouse

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This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.



The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.



In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

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Detail Information

Series Title

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Call Number

363.92 GUE g

Publisher

: ., 2015

Collation

XVII, 408

Language

English

ISBN/ISSN

978-3-662-44286-9

Classification

363.92

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Genetics and Genomics

Specific Detail Info

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Statement of Responsibility

Jean Louis Guénet

Other Information

Cataloger

Khusnun

Source

-

Validator

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