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Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing

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Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.

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Detail Information

Series Title

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Call Number

615

Publisher

: ., 2015

Collation

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Language

English

ISBN/ISSN

978-3-658-10161-9

Classification

615

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Pharmacology
Cancer Biology

Specific Detail Info

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Statement of Responsibility

Hamed Alborzinia

Other Information

Cataloger

Firli

Source

https://link.springer.com/book/10.1007/978-3-658-10161-9

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