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Adhesion G Protein-coupled Receptors: Molecular, Physiological and Pharmacological Principles in Health and Disease

Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.

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Detail Information
Series Title
Handbook of Experimental Pharmacology
Call Number
615 ADH a
Publisher
Cham, Switzerland : Springer.,
Collation
XIV, 403
Language
English
ISBN/ISSN
978-3-319-41523-9
Classification
615
Content Type
text
Media Type
computer
Carrier Type
online resource
Edition
Ed. 1
Subject(s)
Pharmacology
Human Physiology
Specific Detail Info
-
Statement of Responsibility
Other Information
Cataloger
umi
Source
https://link.springer.com/content/pdf/10.1007/978-3-319-41523-9.pdf?pdf=button
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