Text

Admixture Dynamics, Natural Selection and Diseases in Admixed Populations

---

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

---

Availability

No copy data

Detail Information

Series Title

Springer Theses

Call Number

KD 613 JIN a

Publisher

: Springer., 2015

Collation

XIX, 114

Language

English

ISBN/ISSN

978-94-017-7408-6

Classification

613

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

Ed. 1

Subject(s)

Medical Genetics
Bioinformatics
Population Genetics

Specific Detail Info

-

Statement of Responsibility

Wenfei Jin

Other Information

Cataloger

umi

Source

https://link.springer.com/content/pdf/10.1007/978-94-017-7408-6.pdf?pdf=button

Validator

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment