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Agammaglobulinemia

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This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton’s tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia. Patients’ management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are discussed. The book’s closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.

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Detail Information

Series Title

Rare Diseases of the Immune System

Call Number

610 AGAM a

Publisher

Cham, Switzerland : Springer Cham., 2015

Collation

IX, 119

Language

English

ISBN/ISSN

978-3-319-22714-6

Classification

610

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

Ed. 1

Subject(s)

Hematology
Immunology

Specific Detail Info

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Statement of Responsibility

Editor: Alessandro Plebani, Vassilios Lougaris

Other Information

Cataloger

umi

Source

https://link.springer.com/content/pdf/10.1007/978-3-319-22714-6.pdf?pdf=button

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