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Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer

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This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.

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Detail Information

Series Title

AAPS Advances in the Pharmaceutical Sciences Series

Call Number

615.4 ANT a

Publisher

Cham, Switzerland : Springer Cham., 2015

Collation

X, 252

Language

English

ISBN/ISSN

978-3-319-13081-1

Classification

615.4

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

Ed. 1

Subject(s)

Pharmaceutics

Specific Detail Info

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Statement of Responsibility

Editor: Jeffrey Wang, Wei-Chiang Shen, Jennica L. Zaro

Other Information

Cataloger

umi

Source

https://link.springer.com/content/pdf/10.1007/978-3-319-13081-1.pdf?pdf=button

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