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Inflammation and Metastasis

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This book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets. The book includes the topic of the emerging roles of endogenous TLR4 ligands whose functions are shared intriguingly by metastasis and auto-inflammatory diseases such as rheumatoid arthritis. For example, most cancer therapies established so far are effective initially. However, they eventually face the great obstacles of drug resistance, immune evasion, and metastatic progression. One of the endogenous TLR4 ligands is thought to contribute to all three processes. The most important features of the book are to explain a concept of homeostatic inflammation, disturbance of which in the lungs gives rise to the establishment of a pre-metastatic pulmonary microenvironment based on primary tumor-mediated hijacking of the innate immune defense system against respiratory infection. In addition, structure-based thinking is another important feature of this book. It is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, in the center of which cancer is located.

Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases.

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Detail Information

Series Title

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Call Number

616.9 INF

Publisher

: ., 2015

Collation

XX, 505

Language

English

ISBN/ISSN

978-4-431-56022-7

Classification

616.9

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Cancer Research

Specific Detail Info

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Statement of Responsibility

Yoshiro Maru

Other Information

Cataloger

Khusnun

Source

-

Validator

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Digital Object Identifier (DOI)

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Journal Volume

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Journal Issue

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Subtitle

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