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Resistance of Cancer Cells to CTL-Mediated Immunotherapy

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This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

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Series Title

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Call Number

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Publisher

Cham, Switzerland : Springer Cham., 2015

Collation

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Language

English

ISBN/ISSN

978-3-319-17807-3

Classification

NONE

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

Ed. 1

Subject(s)

Cancer Research

Specific Detail Info

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Statement of Responsibility

Benjamin Bonavida

Other Information

Cataloger

Firli

Source

https://link.springer.com/book/10.1007/978-3-319-17807-3#book-header

Validator

maya

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