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Resistance to Photodynamic Therapy in Cancer

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This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.

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Series Title

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Call Number

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Publisher

Cham, Switzerland : Springer Cham., 2014

Collation

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Language

English

ISBN/ISSN

978-3-319-12730-9

Classification

NONE

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

Ed. 1

Subject(s)

Cancer Research

Specific Detail Info

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Statement of Responsibility

Valentina Rapozzi

Other Information

Cataloger

Firli

Source

https://link.springer.com/book/10.1007/978-3-319-12730-9

Validator

maya

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