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Advances in Protein Chemistry

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The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and
fragmentation. L-tyrosine and protein bound tyrosine are prone to attack by various mediators and reactive nitrogen intermediates
to form 3-nitrotyrosine (3-NT). 3-NT formation is also catalyzed by a class of peroxidases utilizing nitrite and hydrogen peroxide as
substrates. Evidence supports the formation of 3-NT in vivo in diverse pathologic conditions and 3-NT is thought to be a relatively
specific marker of oxidative damage. The formation of nitrotyrosine represents a specific peroxynitrite-mediated protein modification;
thus, detection of nitrotyrosine in proteins is considered as a biomarker for endogenous peroxynitrite activity. Formation of tyrosine
nitrated proteins is considered to be a post-translational modification with important pathophysiological consequences and is one of the
markers of nitrosative stress that have been reported in neurodegeneration, inflammatory and other pathological conditions.

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Detail Information

Series Title

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Call Number

572 ADV

Publisher

: OMICS Group., 2013

Collation

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Language

English

ISBN/ISSN

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Classification

572

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Chemistry
Biochemistry
Protein

Specific Detail Info

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Statement of Responsibility

Penyunting, Ghulam Md Ashraf, Ishfaq Ahmed Sheikh

Other Information

Cataloger

umi

Source

-

Validator

maya

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