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Biochemistry and Application in Medicine
Diabetes mellitus is a group of metabolic disorders leading to defects in insulin se-
cretion and action of insulin or both. Diabetes is caused by a combination of hereditary and
environmental factors. In the human body, blood glucose levels are controlled by a complex
interaction of multiple chemicals and hormones, including insulin and glucagon. Insulin is a
peptide hormone produced in the beta cells of the pancreas that allows blood glucose to enter
various cells of the body where it is oxidized to yield energy needed by the muscles and tissues
to function [1]. Glucagon is also a peptide hormone, produced by the alpha cells of the pan-
creas, which causes a rise in the concentration of glucose in the blood. The effect of glucagon
is opposite to that of insulin, which lowers the glucose concentration.
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