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Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders
Development of powerful new highthroughput
technologies for probing the transcriptome, proteome and metabolome is driving the rapid
acquisition of information on the function of molecular systems. The importance of these
achievements cannot be understated –they have
transformed the nature of both biology and medicine.
Despite this dramatic progress, one of the greatest
challenges that continues to confront modern
biology is to understand how behavior at the level
of genome, proteome and metabolome determines
physiological function at the level of cell, tissue and organ in both health and disease. Because of the
inherent complexity of biological systems, the development, analysis, and validation of integrative
computational models based directly on experimental data is necessary to achieve this understanding.
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