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Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

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Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis

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Detail Information

Series Title

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Call Number

610 POL

Publisher

Basel : MDPI - Multidisciplinary Digital Publishing Institute., 2019

Collation

-

Language

English

ISBN/ISSN

978-3-03921-153-1

Classification

610

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Medicine

Specific Detail Info

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Statement of Responsibility

Penyunting, Tracy Murray-Stewart

Other Information

Cataloger

Khusnun

Source

-

Validator

maya

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