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Transient Receptor Potential (TRP) Channels in Drug Discovery : Old Concepts & New Thoughts

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The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed.

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Detail Information

Series Title

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Call Number

615 TRA

Publisher

Basel : MDPI - Multidisciplinary Digital Publishing Institute., 2018

Collation

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Language

English

ISBN/ISSN

978-3-03842-638-7

Classification

615

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Therapeutics

Specific Detail Info

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Statement of Responsibility

Penyunting, Arpad Szallasi, Susan M. Huang

Other Information

Cataloger

Kholif Basri

Source

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Validator

maya

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