Image of Self-Assembled Molecules – New Kind of Protein Ligands
Bookmark Share

Text

Self-Assembled Molecules – New Kind of Protein Ligands

The standard substrate complexation mechanism engages natural binding sites. In contrast, supramolecular structures may form complexes with proteins by
penetrating in regions which are either naturally unstable or become temporarily accessible due to structural
rearrangements related to the protein’s function.
This may result in enhancement of irreversible
processes (e.g. immune complexation or complement
activation) or inhibition of reversible processes (e.g. enzymatic catalysis). Only ribbon-like supramolecular
structures may form complexes with proteins. Having
anchored itself inside the protein, the supramolecular ligand is protected against environmental factors
such as changes in pH. This type of interaction represents
a unique, nonstandard phenomenon in the context
of proteomics.

Availability

No copy data

Detail Information
Series Title
-
Call Number
540 SEL
Publisher
Cham : Springer.,
Collation
-
Language
English
ISBN/ISSN
978-3-319-65639-7
Classification
540
Content Type
text
Media Type
computer
Carrier Type
online resource
Edition
-
Subject(s)
Chemistry
Self-Assembled Molecules
Specific Detail Info
-
Statement of Responsibility
Other Information
Cataloger
Jemadi
Source
-
Validator
Taufik
Digital Object Identifier (DOI)
-
Journal Volume
-
Journal Issue
-
Subtitle
-
Parallel Title
-
Other version/related

No other version available

File Attachment
Comments
You must be logged in to post a comment