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The EBMT/EHA CAR-T Cell Handbook

Nicolaus Kröger - Personal Name; Curaj - Personal Name; John Gribben - Personal Name; Christian Chabannon - Personal Name; Ibrahim Yakoub-Agha - Personal Name; Hermann Einsele - Personal Name;

Chimeric antigen receptor T cell therapy (CAR-T) is a new class of medicinal products that are genetically engineered from T cells. It is expected that other forms of
Immune Effector Cells-based therapies will soon reach the market, manufactured
from other subsets of immune cells, and engineered through other technologies than
currently used defective retroviral or lentiviral vectors. Cell-based immunotherapies
add to the broader feld of immunotherapies, now populated with monoclonal antibodies including immune checkpoint inhibitors, immune-conjugates, and bi- and
tri-specifc antibodies. Approximately 30 years after the frst publications reporting
on the development of genetically engineered T cells, expression of a frst generation chimeric antigen receptor (CAR), and the demonstration of its capability to
recognize antigens in the absence of MHC presentation in the 1980s, the frst commercially available CAR-T cell medicinal products were approved by the FDA and
later by the EMA for the treatment of relapsed/refractory diffuse large B cell lymphoma and relapsed/refractory acute lymphoblastic leukemia.


Availability
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220123015
Available
Detail Information
Series Title
-
Call Number
-
Publisher
: Springer Cham., 2022
Collation
X, 237
Language
English
ISBN/ISSN
9783030943530
Classification
-
Content Type
-
Media Type
computer
Carrier Type
online resource
Edition
-
Subject(s)

The EBMT
EHA CAR
T Cell Handbook
Specific Detail Info
-
Statement of Responsibility
Curaj Nicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele
Other Information
Cataloger
angga
Source
-
Validator
-
Digital Object Identifier (DOI)
https://link.springer.com/book/10.1007/978-3-030-94353-0
Journal Volume
-
Journal Issue
-
Subtitle
-
Parallel Title
-
Other version/related

No other version available

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  • The EBMT/EHA CAR-T Cell Handbook
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