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Natural Antibodies in Health and Disease
Natural antibodies (NAbs) are found in normal
individuals in the absence of exogenous antigenic
stimulation. Natural antibodies rapidly recognize
and protect against pathogens that have not been
previously encountered. NAbs also cross-react with
several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the
ability to perform important housekeeping functions
in healthy organisms. Such housekeeping functions
include the clearance of oxidized damaged structures
and/or apoptotic cells, which prevents the induction
of pro-inflammatory effects. In addition,
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