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Advances in Mechanisms of Renal Fibrosis

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Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney
disease and is considered a common pathway leading to end-stage of renal failure. Renal fibrosis
involves a complex interplay between intrinsic kidney cells, leukocytes, and fibroblasts in which
transforming growth factor-β (TGF-β) plays a key role. Inhibition of TGF-β1 suppresses renal
fibrosis in a number of animal models; however, TGF-β1 is also a negative regulator of the immune
response so that targeting this key factor has been a difficult proposition

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Publisher

: Frontiers Media SA., 2018

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Language

English

ISBN/ISSN

9782889454990

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NONE

Content Type

text

Media Type

computer

Carrier Type

online resource

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Subject(s)

Mechanisms of Renal Fibrosis

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Angga

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Digital Object Identifier (DOI)

https://www.frontiersin.org/research-topics/3106/advances-in-mechanisms-of-renal-fibrosis/magazine

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