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Advances in Molecular Genetics of Brain Tumors
Deregulation of signalling pathways that regulate cell growth, survival, metabolism,
and migration can frequently lead to the progression of cancer. Brain tumours are a large group
of malignancies characterised by inter- and intratumoral heterogeneity, with glioblastoma (GBM)
being the most aggressive and fatal. The present study aimed to characterise the expression of cancer
pathway-related genes (n = 84) in glial tumour cell lines (A172, SW1088, and T98G). The transcriptomic
data obtained by the qRT-PCR method were compared to different control groups, and the most
appropriate control for subsequent interpretation of the obtained results was chosen
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