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Beyond the conventional Renin Angiotensin System
Evidence for the potential role of organ specific cardiovascular renin–angiotensin systems
(RAS) has been demonstrated experimentally and clinically with respect to certain cardiovascular and renal diseases. These findings have been supported by studies involving
pharmacological inhibition during ischemic heart disease, myocardial infarction, cardiac
failure; hypertension associated with left ventricular ischemia, myocardial fibrosis and left
ventricular hypertrophy; structural and functional changes of the target organs associated
with prolonged dietary salt excess; and intrarenal vascular disease associated with endstage renal disease
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