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Bioactive Marine Heterocyclic Compounds
Exploration for specialized metabolites of Okinawan marine sponges Agelas spp.
resulted in the isolation of five new bromopyrrole alkaloids, agesasines A (1) and B (2),
9-hydroxydihydrodispacamide (3), 9-hydroxydihydrooroidin (4), and 9E-keramadine (5).
Their structures were elucidated on the basis of spectroscopic analyses. Agesasines A (1) and
B (2) were assigned as rare bromopyrrole alkaloids lacking an aminoimidazole moiety, while 3–5
were elucidated to be linear bromopyrrole alkaloids with either aminoimidazolone, aminoimidazole,
or N-methylated aminoimidazole moieties
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