Electronic Resource

Amyloid-beta clearance in Alzheimer's disease

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Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.

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Detail Information

Series Title

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Call Number

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Publisher

: Frontiers Media SA., 2015

Collation

111 hlm; ill., lamp.,

Language

English

ISBN/ISSN

9782889194438

Classification

NONE

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

-

Subject(s)

Neurosciences

Specific Detail Info

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Statement of Responsibility

Robert Marr ; Eliezer Masliah

Other Information

Cataloger

ida

Source

https://directory.doabooks.org/handle/20.500.12854/40785

Validator

-

Digital Object Identifier (DOI)

10.3389/978-2-88919-443-8

Journal Volume

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Journal Issue

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Subtitle

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Parallel Title

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