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Arteriogenesis and Therapeutic Angiogenesis

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Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body’s own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.

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Detail Information

Series Title

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Call Number

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Publisher

Basel, 2022 : MDPI - Multidisciplinary Digital Publishing Institute., Basel, 2022

Collation

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Language

English

ISBN/ISSN

9783036527178

Classification

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Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Medicine and Nursing

Specific Detail Info

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Statement of Responsibility

Quax, Paul

Other Information

Cataloger

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Source

https://directory.doabooks.org/handle/20.500.12854/78741

Validator

Suwardi

Digital Object Identifier (DOI)

10.3390/books978-3-0365-2717-8

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