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Chapter 11 Vitamin C and the Brain

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The brain requires vitamin C to metabolize fuel substrates and synthesize neurotransmitters, regulate their release, and modify their actions. Vitamin C also protects the brain from oxidative damage. Clinical studies do not provide strong evidence that vitamin C deficiency directly impairs brain function but rather suggest that the fatigue, mood disturbance, and cognitive dysfunction sometimes associated with vitamin C deficiency are due to peripheral tissue damage, with possibly an exaggerated emotional response to it. Severe brain injury drastically depletes the cerebrospinal fluid of vitamin C; clinical trials of high-dose intravenous vitamin C are strongly warranted for this condition. The very limited clinical trial evidence available does not demonstrate that vitamin C supplementation slows the progression of dementia or improves clinical outcomes after an acute ischemic stroke. Hypovitaminosis C is common in people with severe mental illness; it should be treated. A few clinical trials have been carried out of low-pharmacologic doses of vitamin C (alone or with other nutrients) as adjunctive therapy in patients with chronic stable schizophrenia or depression, with inconsistent results. There is plausible but inclusive evidence that continuous supplementation with a combination of several micronutrients, including vitamin C, may have cognitive benefits in some people even if they lack diagnosed vitamin deficiencies.

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: Taylor & Francis., 2020

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Language

English

ISBN/ISSN

9781138337992, 9781032175256

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NONE

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text

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computer

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online resource

Edition

1

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Hasan

Source

https://directory.doabooks.org/handle/20.500.12854/112600

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Digital Object Identifier (DOI)

10.1201/9780429442025-11

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