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Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism

Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings.

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Call Number
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Publisher
Springer Nature : Springer Nature.,
Collation
oer.unej.ac.id
Language
English
ISBN/ISSN
9783030344597
Classification
NONE
Content Type
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Media Type
computer
Carrier Type
online resource
Edition
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Subject(s)
systems biology
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Statement of Responsibility
Other Information
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Source
https://directory.doabooks.org/handle/20.500.12854/84053
Validator
Suwardi
Digital Object Identifier (DOI)
10.1007/978-3-030-34461-0_38
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