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BRCA1 and BRCA2 Mutations

Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug therapy, and prophylactic surgery can reduce cancer-related morbidity and mortality. In recent years, there has been substantial development in BRCA-associated hereditary breast and/or breast-ovarian cancer research and its clinical applications. In this context, this book consolidates the recent advances in BRCA-related cancer biology and therapeutics, covering a wide spectrum of interrelated topics. Chapters cover a wide range of topics, such as BRCA discovery, BRCA structure and function, BRCA-associated cancers, BRCA genetic testing and counselling, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants.

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Detail Information
Series Title
-
Call Number
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Publisher
: InTechOpen.,
Collation
134 hlm., lamp.,
Language
English
ISBN/ISSN
9781803568089
Classification
NONE
Content Type
text
Media Type
computer
Carrier Type
online resource
Edition
-
Subject(s)
Medical Genetics
Specific Detail Info
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Statement of Responsibility
Other Information
Cataloger
ida
Source
https://directory.doabooks.org/handle/20.500.12854/97315
Validator
-
Digital Object Identifier (DOI)
10.5772/intechopen.100842
Journal Volume
-
Journal Issue
-
Subtitle
-
Parallel Title
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