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Breaking the cycle : Attacking the malaria parasite in the liver

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Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium from the liver. However, malaria liver stage immunity is complex. The anatomic site of priming of naive Plasmodium-specific CD8 T cells, be it in the lymph nodes draining the site of Plasmodium antigen deposition by the mosquito or in the liver, may in fact determine the specificity of the effector CD8 T cells. The participation of particular antigenpresenting cells (Corradin and Levitskaya, 2014) and tissue signatures that influence the activation of intrahepatic CD8 T cells against malaria sporozoites (Morrot and Rodrigues, 2014) are still
incompletely understood. Similarly, how effector CD8 T cells detect the few infected hepatocytes in the large liver and the mechanisms they use to kill the intracellular parasites are unknown.

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Detail Information

Series Title

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Call Number

616 BRE

Publisher

: Frontiers Media SA., 2015

Collation

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Language

English

ISBN/ISSN

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Classification

616

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

-

Subject(s)

Malaria parasite

Specific Detail Info

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Statement of Responsibility

Penyunting, Ute Frevert; Urszula Krzych; Thomas L. Richie

Other Information

Cataloger

maya

Source

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Validator

maya

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